Potential therapeutic targets for Parkinson's disease.
Identifieur interne : 002152 ( Main/Exploration ); précédent : 002151; suivant : 002153Potential therapeutic targets for Parkinson's disease.
Auteurs : Jon Stoessl [Canada]Source :
- Expert opinion on therapeutic targets [ 1744-7631 ] ; 2008.
English descriptors
- KwdEn :
- Animals, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Biomarkers, Pharmacological, Disease Models, Animal, Disease Progression, Dopamine (metabolism), Drug Delivery Systems, Drug Design, Genetic Therapy, Humans, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology).
- MESH :
- chemical , metabolism : Dopamine.
- chemical , pharmacology : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Animals, Biomarkers, Pharmacological, Disease Models, Animal, Disease Progression, Drug Delivery Systems, Drug Design, Genetic Therapy, Humans.
Abstract
Parkinson's disease is a common disorder that becomes more prevalent with advanced age. The cardinal features are related to dopamine deficiency, arising from loss of neurons projecting from the substantia nigra in the midbrain to the striatum. Therapies based on dopamine replacement are well established but while highly effective, leave a number of currently unmet needs. These include features of disease that are probably not related to dopamine deficiency and are unresponsive to dopamine-replacement therapy, as well as complications of long-term dopaminergic therapy itself. The most important gap is the availability of treatments that modify the inexorable progression of disease or that could prevent its onset in subjects at risk.
DOI: 10.1517/14728222.12.4.425
PubMed: 18348679
Affiliations:
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Le document en format XML
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The cardinal features are related to dopamine deficiency, arising from loss of neurons projecting from the substantia nigra in the midbrain to the striatum. Therapies based on dopamine replacement are well established but while highly effective, leave a number of currently unmet needs. These include features of disease that are probably not related to dopamine deficiency and are unresponsive to dopamine-replacement therapy, as well as complications of long-term dopaminergic therapy itself. The most important gap is the availability of treatments that modify the inexorable progression of disease or that could prevent its onset in subjects at risk.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Stoessl, Jon" sort="Stoessl, Jon" uniqKey="Stoessl J" first="Jon" last="Stoessl">Jon Stoessl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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